Home 3D Printing HU3DINKS challenge goals to revolutionize 3D bioprinting with human-like bio-inks

HU3DINKS challenge goals to revolutionize 3D bioprinting with human-like bio-inks

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HU3DINKS challenge goals to revolutionize 3D bioprinting with human-like bio-inks

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A brand new challenge known as Human Bio-inks for 3D printing (HU3DINKS) is aiming to develop human tissue-based bio-inks for 3D bioprinting. Funded by the IraSME initiative, this challenge goals to advertise cross-border collaborations.

The HU3DINKS consortium contains companions from Belgium and Austria. THT Biomaterials (Vienna, Austria) contributes experience in human placenta-derived supplies, whereas BIO INX (Ghent, Belgium) focuses on bio-ink improvement for numerous printing applied sciences. MorphoMed (Vienna, Austria) provides help with medical grade silk expertise, and UpNano (Vienna, Austria) is famend for experience in 2PP (bio) high-resolution bio 3D printing applied sciences. Moreover, the organic validation of the newly developed bio-inks is carried out by the Ludwig Boltzmann Institute for Traumatology, together with AUVA.

“The expertise has made some super advances in efficiency however is now primarily restricted by the absence of high-performing organic supplies. The HU3DINKS challenge can induce a paradigm shift within the discipline by actually mimicking the human mobile setting each by way of structure and composition,” stated, Markus Lunzer, Supplies Specialist at UpNano.

Printing of structures using the 'human ink'. Image via Flam3D.
Printing of constructions utilizing the ‘human ink’. Picture by way of Flam3D.

Towards extra human-like 3D bioprinting

At present, 3D bioprinting predominantly depends on supplies derived from animal sources, like gelatin or collagen. The necessity for animal-free alternate options arises to interchange animal testing and higher resemble human tissue circumstances. Artificial polymers have been explored however lack the complexity of in vivo conditions, failing to bridge the hole between in vitro exams and animal fashions, says the consortium.

The HU3DINKS challenge goals to develop high-performing human tissue-based bio-inks for 3D bioprinting, together with extrusion and high-resolution laser-based strategies. Regardless of business human tissue-derived supplies being obtainable, their bioactivity and 3D printing efficiency stay poor. Thus, the HU3DINKS consortium seeks to transform these supplies into bio-inks for extra environment friendly 3D printing.

Consequently, 3D printed human tissue fashions supply a extra correct illustration of native 3D tissues in comparison with conventional 2D cell tradition strategies. This permits for testing medication or cosmetics on these fashions, aligning with the 3R precept of decreasing, changing, and refining animal utilization in scientific analysis.

The aim is achieved by means of high-resolution bioprinting, notably with using 2-photon polymerization (2PP). This expertise permits for subcellular decision, successfully mimicking complicated microcellular structure. Furthermore, 2PP is among the few strategies that facilitate direct printing inside microfluidic chips, streamlining the drug screening course of.

Microvascular structure. Image via Flam3D.
Microvascular construction. Picture by way of Flam3D.

Bioprinting: A brand new approach to restore and change broken tissue

Final yr, 3D bioprinting specialist CollPlant launched a bio-ink generally known as ‘Collink.3D 90’ to its materials portfolio previously. This second recombinant human collagen (rhCollagen)-based materials was distinguished by its improved mechanical properties, particularly tailor-made to satisfy the 3D printing calls for of arduous and tender tissues. Moreover, the ink was reported to speed up cell migration, surpassing current cell-culturing hydrogels on this facet. This attribute made it a “promising alternative” for the event of regenerative medicines, says CollPlant.

Finnish bioprinting firm Brinter, allied with Tampere College‘s Kellomäki Lab Biomaterials and Tissue Engineering Group to discover bio-inks for 3D printing and drive “developments within the bioprinting discipline.” Their first breakthrough concerned the event of a novel methodology to create a photocrosslinkable bio-ink from gellan gum, a precursor identified for its favorable rheological properties in hydrogels. Using a two-step crosslinking approach, the workforce efficiently remodeled beforehand unprintable gellan gum inks into viable bio-inks, enabling the fabrication of 3D printed constructions. Moreover, the workforce proposed the potential of making use of this method to numerous different bioink formulations.

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Featured picture exhibits HU3DINKS emblem. Picture by way of Flam3D.



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