Just lately, nice progress has been made in nanozyme analysis because of the fast improvement of nanomaterials and nanotechnology. MXene-based nanomaterials have gained appreciable consideration as a consequence of their distinctive physicochemical properties. They’ve been additionally discovered to have excessive enzyme-like properties similar to peroxidase, oxidase, catalase, and superoxide dismutase. On this mini-review, an outline of the latest progress of MXene-based nanozymes is introduced, with the emphasis on their artificial strategies, hybridization, bio-catalytic properties, and biomedical purposes. Lastly, the longer term challenges and prospects of MXene-based nanozymes are additionally proposed.