Just lately, two-dimensional transition steel dichalcogenides (TMDs) reminiscent of molybdenum disulfide (MoS2) have attracted nice consideration as a consequence of their distinctive properties. To modulate digital properties and construction of TMDs, it’s essential to exactly management chalcogenide vacancies and several other strategies have been already urged. Nonetheless, they’ve a number of limitations reminiscent of plasma injury by ion bombardment. Herein, we launched a novel solvent-assisted emptiness engineering (SAVE) methodology to modulate sulfur vacancies in MoS2. Contemplating polarity and Hansen solubility parameter (HSP), three solvents have been chosen. Sulfur vacancies might be modulated by immersing MoS2 in every solvent, supported by X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy analyses. SAVE methodology can additional increase its utility in reminiscence gadgets representing memristive efficiency and synaptic behaviors. We represented the cost transport mechanism of sulfur vacancies forming and breaking conductive hyperlinks. The non-destructive, scalable, and novel SAVE methodology controlling sulfur vacancies is anticipated to be a suggestion for developing a emptiness engineering system of TMDs.